Our book, “The Great Age Reboot, Cracking the Longevity Code for a Younger Tomorrow” tells the story of how longevity became the greatest disruptor of all time, and how you can take advantage of it.
Scientific research into the mechanisms of aging is advancing as computing has done over the past decade: exponentially. Over the past 150 years, life expectancy at birth in the United States has increased from approximately 41 to 78 years. This gain in life expectancy since 1870 has occurred on a relatively straight line of about 2 1/2 years of gain every 10 years. Initially due to improved sanitation and child health, and later to the management of chronic conditions such as high blood pressure and diabetes.
And research indicates that we are likely (over 80% chance, we estimate) to get a 30-year exponential jump in life expectancy. In the next 10 years, you will be able to live longer and younger. This jump in your lifespan is due to exponential progress in aging research (I like Diamondis’ explanation of this exponential progress – 30 linear steps equals 30 meters; but 30 exponential steps – 1.2, 4,8,16,32 – circles the earth 26 times). This shows how fast research on the mechanisms of aging is advancing, and how important this disruptor will be for you and for society.
Pick any age – let’s say you’re 55 – your life expectancy was 74 when you were born – now it’s 82. jump – 30 or more years of life in just 10 years – is unprecedented.
You might be wondering what that longevity looks like? What should you do to prepare to be younger? After all, who wants to live longer if it just means living longer?
But hear us out: you won’t just live longer. Instead, you will extend the period between 30 and 60 years old to between 30 and 90 years old. And with longer working lives, you and society can afford it. The Great Age Reboot is all about opportunity. The Opportunity to Change Every Life – Yours Too – for the Better – and the Opportunity to Stop Worrying About Medicare and Social Security Trust Funds Running Out of Money – CBO Predicts All Trust Funds will be bankrupt in the early 2030s and that the increase in the population of the United States will decline in percentage terms to less than during the depression of the 1930s – and the opportunity to significantly reduce inequality. (These topics need more space, so we’ll discuss them next week).
To further tease next week’s article, and to be specific, the CBO predicts that the population of the United States will only increase by 34 million more by 2050; we believe using their birth rate and immigration numbers, but the Great Age Reboot prediction on death rates, that our population growth will be closer to 117 million – a 250% difference in growth rates, and it will create a great economic boom.
We’ve selected 14 of the most important areas of aging research to keep an eye out for as the big game changers for longevity (there are many more). Now you might be wondering what the 14 areas are and why haven’t you heard of them or why didn’t your doctor tell you about them – it’s because research is now progressing so rapidly in each of the 14 areas make it difficult to follow. The 14 areas of exponential gains are:
Production of stem cells without immunogenicity; and repair of dysfunctional cells (generating cells that can replace and replace the original cells and function as if the original cells)
Autophagy with and without intermittent fasting and from five days of calorie/sugar/protein restriction (a parts-recycling process that rejuvenates you)
Senolytics, including therapeutic plasma exchange (the harvesting of old cells and proteins that age neighbors)
Gene editing (CRISPr and CAS9 and enhancements) with immunomodulation (modifying your genes to get rid of errors and genes that age you)
Induced tissue regeneration (resetting your genes to their original factory settings)
Epigenetic reprogramming and rebooting (resetting the switches that govern which of your genes are on or off to their original settings)
Telomere regeneration (allowing your repair systems to repair you for longer)
Immunotherapy and immunological targeting (uses your immune system to rid itself of cancer and other chronic diseases)
Hormetic hyperbaric oxygen therapy (using oxygen in a way that tricks the body into increasing tissue repair mechanisms)
Mitochondrial restoration and elimination of obesity and its consequences with transformation of white fat into brown fat
Microbiome reprogramming and photomodulation (using the bacteria and other organisms that inhabit your body and gut and energy therapies to help you reboot younger)
Reduce inflammaging (reduce inflammation in your body)
Bionic bodies (artificially created organs and tissues)
Proteostasis (keeping your proteins as they were when you were younger)
Here are two examples of the reboot’s exponential progression from “The Great Age Reboot” book:
1. On May 7, 2020, a research article reported that scientists in India and Los Angeles had teamed up in an epigenetic reprogramming study to make a 107-week-old rat (the human equivalent of 104 years old) with four injections of a readily available substance a 30-week-old rat (about 35 years old in human terms). Imagine if we could do it for you – human trials have begun.
2. Elimination of a genetic mutation in liver cells that produces abnormal amyloid and causes 25-30% of heart failure has been reported in two animal species. It was thought that its use in humans with heart failure could extend life expectancy from less than six months to over 18 years in people who could literally only sit and watch TV with their fractions of ejection (the fraction of blood in the left ventricle of the heart that is sent to the rest of the body with each cardiac contraction) were less than 12%. In its first human test in Australia, this genetic modification reversed heart failure in seven out of 12 patients with amyloid heart failure and increased ejection fractions to around 35%. These seven people have gone from living in a chair to playing ball and swimming with their grandchildren.
And in New Zealand, such a genetic modification is being tested to radically reduce the risk of high LDL cholesterol causing heart disease and stroke by knocking out a gene that prevents LDL from being metabolised. And since most cancers are caused by a genetic error, a huge amount of research is now devoted to finding inexpensive ways to target these genes. Indeed, all signs point to a near future where genetic diseases will become fully curable.
It’s important to remember that it’s still early days, and these examples are just a few of the exponential gains that mean for us that with an 80% chance or more of being able to turn 40 by the calendar age of 90 years old.
It’s what we tell you – between advances in medicine and the choices you make – that you will have the ability not only to live longer, but also to live younger and better. Yes, illnesses and accidents will happen, and they won’t always be your fault. But as COVID-19 has shown, your choices and your state of health before contracting the disease or accident will significantly influence the likelihood of the risk that the disease presents to you. And add the progress that will soon be here, and a lot will change. What if we told you that you would feel 45 at 80, 55 at 95-100, and active 75 at over 120? Let’s face it: it’s an entirely different proposition.
More specifically, this means the following:
1. Personal decisions (medical and financial, good and bad) matter more when the consequences last longer.
2. This major societal disruptor will cause growing pains, but is ultimately a positive development. Society will have the resources to manage these extended lifespans since longevity is not the issue; it is the remedy.
NEXT: Over the next two weeks in the CJN, we’ll be discussing these last two concepts and the enormous economic and social benefits this longevity disruptor can bring to you and society if you and policymakers are successful in helping you and others think through these questions is really why we wrote the book.